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Additional guidance

According to the instructions, "Mirtazapine" should be used very carefully in the following cases:

  • in the presence of defects in urination;
  • with diabetes.

This drug should also not be combined with alcohol, as this can cause nausea. If violations of the liver and kidneys are noted, the patient is advised not to use this antidepressant, since its main active ingredient will affect these organs. https://perfecthealthus.com/buy-mirtazapine-15mg-30mg-online/ In addition, antidepressants are usually not used in complex treatment..

Overdose

Taking a larger dose of the drug than indicated in the recommendations entails an excess of the amount of the drug in the body, intoxication. Signs of poisoning are:

  • confusion
  • drowsiness
  • memory problems
  • fast heart rate

At the first manifestations of drug poisoning, you need to urgently seek emergency first aid.

To achieve the maximum therapeutic effect from the use of the drug, you need to take tablets at the same time of the day. If you forgot to take the medicine on time, drink the tablets as soon as you remember. If several hours are left before using the next portion of the medication, leave the forgotten dose. You do not need to take a double portion to make up for the missed. Such actions are potentially hazardous to health..

Mirtazapine Canon is used for long-term treatment. The therapeutic effect can begin to manifest itself noticeably only at 4 weeks of healing.

Mirtazapine: instructions for use, price, reviews, analogues

Preparations with this active substance (trade names)

Latin name of the substance

Antidepressant tetracyclic structure. http://mirtazapineremeronsa.com/ Enhances central adrenergic and serotonergic transmission.

It blocks serotonin 5-HT2 and 5-HT3 receptors, in this regard, increased serotonergic transmission is realized only through serotonin 5-HT1 receptors.

Both spatial enantiomers are involved in the manifestation of antidepressant activity: S (+) - the enantiomer blocks α2-adrenergic receptors and serotonin 5-HT2 receptors. Moderately blocks histamine H1 receptors, has a sedative effect.

Little effect on α1-adrenergic receptors and cholinergic receptors; in therapeutic doses does not significantly affect the cardiovascular system.

In clinical conditions, anxiolytic and hypnotic effects are also manifested, therefore, mirtazapine is most effective for anxious depressions of various origins. Due to the moderate sedative effect in the treatment process, suicidal thoughts are not actualized.

Mirtazapine after oral administration is rapidly absorbed from the digestive tract. Bioavailability is 50%. Cmax in blood plasma is reached after 2 hours.

Css in plasma is established after 3-4 days of constant use. Plasma protein binding is 85%.

It is actively metabolized in the liver by demethylation and oxidation, followed by conjugation. Dimethyl-mirtazapine is as pharmacologically active as the starting material.

Mirtazapine is excreted by the kidneys and through the intestines. T1 / 2 is 20-40 hours.

With renal and hepatic insufficiency, a decrease in the clearance of mirtazapine is possible.


by monica3clark | 2020-09-15 16:55